Endocrine Abstracts

Aim: Assess the effectiveness of management of pregnant women with type 1 diabetes mellitus (DM 1) with continuous subcutaneous insulin infusion (CSII).Materials and Methods: Pregnant women with DM 1 with CSII (n=21) - the main group and on multiple daily insulin injections (MDI) (n=216) - the comparison group. We used different models of the Medtronic pumps. The inclusion in the comparison group carried out by a continuous method. The ...

Introduction: The presence of diabetes-associated antibodies is an indicator of β-cell destruction. Our goal was to find out the prevalence of autoantibodies associated with the new onset of type 1 diabetes mellitus (DM1) without family history.Subjects and Methods: 22 patients (10 women and 12 men) with newly diagnosed DM1 no family history were examined. Average age of patients was 31.7±7.3 y.o., experience of DM1 was 2.3±0.8 months. All the...

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. Various approaches are used to achieve this goal. We initiated a study to assess the potential effect of the cell therapy based on autologous Tolerogenic Dendritic Cells on the newly diagnosed DM1 (NCT05207995, ClinicalTrials.gov).Methods: 4 patients who were injected with Tolerogenic...

The diagnostic possibilities of using biochemical markers of bone metabolism in patients with secondary hyperparathyroidism (SHPT) and chronic kidney disease (CKD) have not yet been adequately evaluated. The aim of the study: To evaluate biochemical markers of bone metabolism in patients with various stages of CKD, their relationship with SHPT and bone mineral density.Materials and Methods: The study included 452 patients with various stages of CKD and 6...

Background and Aim: To study the cardioprotective effects of empagliflozin and vildagliptin in patients with diabetes type 2.Method: 90 patients with type 2 diabetes were randomized using a random number generator into 3 groups, depending on the antihyperglycemic therapy prescribed for the next 6 months: the group that continued to receive gliclazide and metformin, the group in addition to gliclazide and metformin received vildagliptin at a dose of 100 m...

Introduction: The relationship between indicators of carbohydrate, fat and bone metabolism is beyond doubt. It is known that osteocalcin, overcoming the blood-brain barrier, can affect the development of the fetal brain. Adiponectin is currently being considered as a biomarker for pregnancy complications. These facts determined the purpose of the study.Aim: To study the content of osteocalcin and adiponectin in pregnant women with type 1 diabetes (T1DM)....

Our research focused on the role of immune mechanisms in diabetic foot ulcers development and impaired healing. The AIM of this study was to evaluate endogenous interleukin (IL1,4,6,8) production to the culture medium by the skin cells (keratinocytes and fibroblasts) cocultured with mononuclears of patients with type 2 diabetes mellitus (T2DM) and T2DM with chronic foot ulcers (DFU) in a 3D culture model.Materials and methods: A multilayer 3D immunocompe...

AimsDiabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD). Renal impairment may affect not only glycemic control, but also metabolism of biologically active cytokines such as adiponectin. Taking into account multiple effects of adiponectin the purpose of the study was to assess its changes in patients with type 1 diabetes (T1D) and comorbid CKD.Materials and methodsWe recruited 129 pati...

Background and Aims: to assess the relationship between level of interleukin-6 (IL-6) and the renal function in patients with diabetes mellitus (DM).Method: A total of 416 patients with DM, aged 34 to 75 years, were examined. Control group included 60 healthy patients the same age/All patients underwent standard clinical and laboratory examination, with an assessment of the levels of natriuretic peptides (BNP, proBNP) and level of IL-6. Renal function wa...

Recent evidence points to a relationship between the severity of Covid-19 infection and iron metabolism. In patients with type 2 diabetes mellitus (DM 2), the prevalence of anemia of chronic diseases exceeds the general population indicators, which may be one of the factors determining the increase in mortality in this category of patients with Covid-19.Aim: To determine the differences between markers of ferrostatus indicators in patients with DM 2 and ...